The Physiological Mechanisms of Triple Negative Breast Cancer in African American Women

Breast cancer is one of the leading causes cancer-related mortality among women. Multiple subtypes exist for tumor biology, but triple-negative breast (TNBC) lacks expression estrogen receptor, progesterone and human epidermal growth factor. TNBC accounts 20% cancers most aggressive associated with an earlier age susceptibility, racial ethnic differences, limited targeted therapies. African American women bear a disproportionate burden in oncology-related health disparities. This population diagnosed at later stages often regional to distant metastases, high grades, aberrant sequence mutations, treatment delays, decreased disease-free survival. review explores multifactorial nature this disparity by addressing physiological mechanisms, socioeconomic factors, ancestral challenges diagnosis methods era precision medicine.